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Related Concept Videos

Barriers to Effective Communication II01:21

Barriers to Effective Communication II

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The barriers to effective communication also include cultural barriers, semantic barriers, gender barriers, and time constraints.
Cultural barriers:
Differences in values, beliefs, religion, knowledge, and tradition can significantly impact communication. Awareness of nonverbal cues is critical, especially when conversing with a patient from a different culture. What appears appropriate in one culture may be inappropriate in another.
Semantic barriers:
As a result of their tendency to use...
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Patient-centered Care01:13

Patient-centered Care

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Patient-centered care involves delivering care beyond inpatient hospitalization. Reflective practice can enhance a patient-centered approach. Reflective practice is a process of reasoning that considers all aspects of the present situation, including practicalities, learning from personal practice, and consideration of patient needs. Patients appreciate care decisions made while considering their input. Involving the patient in their care provides the patient with a sense of contribution rather...
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Barriers to Effective Communication I01:30

Barriers to Effective Communication I

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A communication barrier is any distortion or interruption during a conversation, resulting in miscommunication of the message. A good communicator should know these barriers and continuously check for the listener's understanding by obtaining feedback.
Communication barriers include the following:
Physiological barriers: They are limitations caused by a person's health condition or disability, such as hearing loss, poor eyesight, illness, or unconsciousness. An example to overcome this...
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Fixing Double-strand Breaks02:04

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The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
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Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit
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Breaking Down Barriers to Effective Patient Care.

Peter H O'Donnell1, Kellie Schoolar Reynolds2

  • 1Department of Medicine, Center for Personalized Therapeutics, and Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago, Chicago, Illinois, USA.

Clinical Pharmacology and Therapeutics
|February 9, 2018
PubMed
Summary

Clinical pharmacology advances drug development from discovery to patient care. Innovations in rare diseases, neurodegenerative disorders, and cancer are breaking down barriers to effective medicine.

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Area of Science:

  • Clinical pharmacology
  • Translational science
  • Drug development

Background:

  • The 2018 ASCPT Annual Meeting theme, "Breaking Down Barriers to Effective Patient Care," highlights clinical pharmacology's role in advancing medicine.
  • Clinical pharmacology encompasses diverse subdisciplines crucial for drug development and post-approval use.

Discussion:

  • New methods for target identification are enabling drug development for rare diseases.
  • Biomarkers and diagnostics are accelerating drug development for neurodegenerative disorders and cancer.
  • Preclinical data and animal efficacy studies inform quantitative clinical pharmacology and regulatory pathways like the animal rule.

Key Insights:

  • Pharmacogenomics, model-based drug development, and informatics are key areas of focus.
  • Subgroup identification and evaluation are critical for personalized medicine.
  • Innovative clinical pharmacology investigations aim to overcome obstacles in patient care.

Outlook:

  • Continued advancements in clinical pharmacology are essential for translating scientific discoveries into effective patient therapies.
  • Interdisciplinary approaches are vital for addressing complex diseases and improving drug utilization.
  • The field is poised to further dissolve barriers, enhancing the delivery of precision medicine.