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Visual perceptual skills and visual motor integration in children and adolescents after allogeneic hematopoietic stem

Kristina Teär Fahnehjelm1,2, Alba Lucia Törnquist1, Monica Olsson1

  • 1Department of Clinical Neuroscience, Karolinska Institutet, St. Erik Eye Hospital, Stockholm, Sweden.

Pediatric Transplantation
|February 9, 2018
PubMed

Insights

Children undergoing hematopoietic stem cell transplant (HSCT) often experience deficits in visual perceptual skills and visual-motor integration (VMI). Early neuropsychological assessment is recommended for these patients.

Area of Science:

  • Pediatric Hematology
  • Neuroscience
  • Ophthalmology

Background:

  • Hematopoietic stem cell transplantation (HSCT) is a critical treatment for various childhood diseases.
  • Long-term effects of HSCT on neurodevelopmental outcomes, particularly visual skills, require further investigation.

Purpose of the Study:

  • To evaluate visual acuity, visual perceptual skills, and visual-motor integration (VMI) in children post-HSCT.
  • To identify factors influencing visual outcomes in pediatric HSCT survivors.

Main Methods:

  • 102 children/adolescents (4.3–20.9 years) who underwent HSCT were assessed.
  • Standardized tests measured visual acuity, visual perceptual skills (memory, form constancy, visual sequential memory), and VMI.
  • Results were compared to age-equivalent normative data.

Main Results:

  • Visual acuity was generally normal (median 1.0 decimal).
  • Significant deficits were observed in visual perceptual skills and VMI, with a high percentage of patients below the 25th percentile.
  • Patients performed significantly below the 50th percentile in visual sequential memory and VMI.

Conclusions:

  • Visual perceptual skill deficits and VMI problems are common sequelae in children after HSCT.
  • Age at HSCT and the original diagnosis impact visual outcomes.
  • Neuropsychological assessments, including visual perception evaluation, are crucial for children post-HSCT.

Keywords:
adverse effectshematopoietic stem cell transplantation

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