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Ethnic differences in spirometry measurements in China: Results from a large community-based epidemiological study
Ruohua Yan1, Lap Ah Tse2, Zhiguang Liu2
1State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Respirology (Carlton, Vic.)
|February 9, 2018
Summary
Spirometry measurements like FEV1 and FVC show significant ethnic differences in China. These variations among Han Chinese and minority groups are not fully explained by known factors, suggesting genetic or environmental influences.
Area of Science:
- Pulmonary Medicine
- Human Genetics
- Environmental Health
Background:
- Spirometry measurements (FEV1, FVC) are crucial for lung function assessment.
- Ethnic variations in lung function within China remain understudied.
- Factors influencing these ethnic differences are largely unknown.
Purpose of the Study:
- To investigate ethnic differences in spirometry measurements (FEV1 and FVC) among various ethnic groups in China.
- To compare lung function parameters between Han Chinese and ethnic minorities (Uygur, Hui, Mongolian, Dai).
Main Methods:
- Recruited 7137 individuals aged 35-70 from diverse ethnic regions in China (2007-2009).
- Conducted spirometry tests on participants.
- Utilized nonlinear multiplicative regression models to compare FEV1 and FVC across ethnicities, adjusting for confounders.
Main Results:
- Analyzed data from 2005 healthy never-smokers.
- Observed significant ethnic variations in FEV1 and FVC.
- Mongolians showed higher FEV1 (4.42%) compared to Han Chinese, while Uygurs (-4.08%), Hui (-4.39%), and Dai (-4.72%) showed lower values, with similar trends for FVC.
Conclusions:
- Significant ethnic differences in spirometry measurements exist among Chinese populations.
- These differences are not fully explained by demographic, anthropometric, or socioeconomic factors.
- Genetic background and environmental exposures likely contribute to observed ethnic variations in lung function.
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