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Metallocyclodextrins in medicinal chemistry
Valentina Oliveri1, Graziella Vecchio1
1Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Viale A Doria, 6, 95125 Catania, Italy.
Future Medicinal Chemistry
|February 9, 2018
Summary
Cyclodextrin (CyD) metal complexes show promise in medicine. These derivatives act as therapeutic and diagnostic agents, mimicking proteins and enhancing imaging and chelation therapies.
Area of Science:
- Coordination Chemistry
- Supramolecular Chemistry
- Medicinal Chemistry
Background:
- Cyclodextrins (CyDs) are versatile cyclic oligosaccharides with hydrophobic cavities.
- Metal complexes incorporating CyD derivatives offer unique properties for biomedical applications.
- This review highlights advancements in CyD-based metal complexes for therapeutic and diagnostic purposes.
Purpose of the Study:
- To review the design and applications of metal complexes based on cyclodextrin derivatives.
- To explore the use of CyDs in creating metalloprotein models and diagnostic agents.
- To discuss the potential of CyD-metal complexes in therapeutic interventions.
Main Methods:
- Review of literature on cyclodextrin-metal complexes.
- Analysis of CyD functionalization strategies for metalloprotein mimetics.
- Examination of CyD scaffolds for multicenter metal complexes and contrast agents.
- Evaluation of CyD ligands for metal chelation therapy.
Main Results:
- CyD derivatives stabilize metalloprotein models like hemoglobin and superoxide dismutase/catalase mimetics, enhancing solubility and activity.
- Paramagnetic CyD-based multicenter metal complexes serve as high-performance MRI contrast agents.
- CyD ligands demonstrate potential in metal chelation therapy due to conferred properties.
Conclusions:
- Metal complexes of cyclodextrin derivatives represent a promising class of compounds for diverse biomedical applications.
- CyD modification enhances the stability, solubility, and biological activity of metal-based therapeutic and diagnostic agents.
- Further research into CyD-metal complexes could lead to novel treatments and advanced diagnostic tools.
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