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Related Experiment Video

Updated: Feb 14, 2026

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Vascular Dysfunction in Exfoliation Syndrome.

Gábor Holló1

  • 1Department of Ophthalmology, Semmelweis University, Budapest, Hungary.

Journal of Glaucoma
|February 9, 2018
PubMed
Summary

Exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) are linked to systemic vascular issues. Research shows widespread vascular dysfunction in XFS/XFG patients, exceeding normal aging, and potentially linked to elastosis and oxidative stress.

Area of Science:

  • Ophthalmology
  • Cardiology
  • Vascular Biology

Background:

  • Exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) are increasingly recognized for their association with systemic vascular diseases.
  • While a uniform clinical relationship remains elusive across diverse populations, evidence consistently points towards vascular dysfunction in affected individuals.

Purpose of the Study:

  • To summarize current knowledge on vascular dysfunction in exfoliation syndrome and exfoliation glaucoma.
  • To explore the pathophysiological mechanisms linking XFS/XFG to systemic vascular abnormalities.

Main Methods:

  • Review of epidemiological and pathophysiological studies investigating vascular health in XFS and XFG.
  • Analysis of reported biomarkers and functional tests indicative of vascular impairment.

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Main Results:

  • Consistent detection of vascular dysfunction in XFS/XFG, including elevated homocysteine, reduced capillary flow, conduit artery dysfunction, and impaired baroreflex sensitivity.
  • Pathophysiological alterations observed in XFS/XFG surpass normal age-related decline.
  • These changes are linked to systemic elastosis and oxidative stress, not solely to specific gene risk alleles.

Conclusions:

  • Vascular dysfunction is a significant, albeit not fully understood, component of exfoliation syndrome and exfoliation glaucoma.
  • Further research is needed to elucidate the mechanisms driving clinically significant vascular consequences such as myocardial dysfunction and stroke.