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Candida-Epithelial Interactions.

Jonathan P Richardson1, Jemima Ho2, Julian R Naglik3

  • 1Mucosal & Salivary Biology Division, Dental Institute, King's College London, London SE1 1UL, UK. jonathan.richardson@kcl.ac.uk.

Journal of Fungi (Basel, Switzerland)
|February 9, 2018
PubMed
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This review explores how Candida fungi interact with human epithelial cells. It details the mechanisms of adhesion, invasion, and mucosal damage during fungal infections.

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Area of Science:

  • Microbiology
  • Immunology
  • Cell Biology

Background:

  • * The human body hosts a complex microbiota, including commensal fungi like *Candida* species.
  • * These fungi continuously interact with epithelial cells at mucosal surfaces.
  • * Environmental changes can disrupt the mucosal balance, leading to fungal overgrowth and infection.

Purpose of the Study:

  • * To review the direct and indirect molecular interactions between *Candida* species and host epithelial cells.
  • * To explore the key factors governing fungal adhesion to mucosal surfaces.
  • * To examine the mechanisms of *Candida* invasion and host tissue destruction.

Main Methods:

  • * Literature review of existing studies on host-fungus interactions.
  • * Analysis of molecular mechanisms underlying *Candida* pathogenesis.
  • * Examination of host responses to *Candida* colonization and infection.

Main Results:

  • * *Candida* species employ diverse strategies to adhere to epithelial cells.
  • * Fungal invasion involves active penetration and manipulation of host cell functions.
  • * Both fungal virulence factors and host responses contribute to mucosal damage.

Conclusions:

  • * Understanding *Candida*-epithelial cell interactions is crucial for combating fungal infections.
  • * Targeting adhesion and invasion mechanisms may offer novel therapeutic strategies.
  • * Further research is needed to fully elucidate the complex interplay between *Candida* and host tissues.