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Updated: Jul 24, 2026

Immunostaining to Visualize Murine Enteric Nervous System Development
Published on: April 29, 2015
[Risk factors associated with the development of enterocolitis in Hirschsprung's disease]
M I Romo Muñoz1, A Martínez de Aragón2, V Núñez Cerezo1
1Servicio de Cirugía Pediátrica. Hospital Universitario Infantil La Paz. Madrid.
Objectives:
Hirschsprung's-associated enterocolitis (HAEC) is a live-threatening complication that remains badly understood. Our objective is to identify the risk factors related to the development of HAEC in the cohort of patients with Hirschsprung's disease (HD) treated in our center.
Methods:
We reviewed the patients treated for HD between 2000 and 2016. Ninety four patients were included, and the clinical details related to the disease were evaluated. Our primary outcome measure was the development of HAEC. Relative risks are presented with 95% confidence intervals.
Results:
Twenty seven patients out of the ninety four (28.7%) suffered HAEC. None of them died from this complication. The extended aganglionosis, the need of a preoperative stoma, a transabdominal surgery and the diagnosis before the age of 7.2 months were related to a higher risk of suffering HAEC.
Conclusions:
HAEC remains a common complication in patients suffering from HD, especially those with complex forms. The identification of the risk factors could result in a better control of the HAEC, which lead to a faster diagnosis and treatment, reducing the morbi-mortality related to HAEC.
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