Related Experiment Video

Updated: Feb 14, 2026

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
08:53

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma

Published on: June 10, 2017

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Syncytial variant of nodular sclerosing Hodgkin lymphoma in children: A prognostic factor?

Noa Granot1, Ayelet Ben-Barak2, Yael Fisher3

  • 1a The Bruce Rappaport Faculty of Medicine , Technion-Israel Institute of Technology , Haifa , Israel.

Pediatric Hematology and Oncology
|February 9, 2018
PubMed

Insights

Syncytial variant (SV) Hodgkin lymphoma (HL) in children, though rare, indicates a poor prognosis. This aggressive form of pediatric HL requires intensive treatment, and its histology may predict outcomes.

Area of Science:

  • Pediatric Oncology
  • Hematology
  • Pathology

Background:

  • Nodular sclerosing Hodgkin lymphoma (HL) typically has an excellent prognosis in children.
  • The syncytial variant (SV) of HL in adults is associated with a worse outcome.
  • Limited data exists on the syncytial variant of HL in pediatric populations.

Purpose of the Study:

  • To report the clinical features and disease course of three children with refractory syncytial variant Hodgkin lymphoma.
  • To evaluate the syncytial variant as a potential prognostic factor in pediatric HL.

Main Methods:

  • Retrospective multi-institutional study.
  • Analysis of 51 children diagnosed with refractory or recurrent HL between 1997 and 2014 in Israel.
  • Detailed review of three pediatric cases with syncytial variant HL histology.

Main Results:

  • All three pediatric patients with SV-HL experienced multiple, rapid recurrences.
  • Intensive treatment regimens were utilized, including multiple chemotherapy combinations, autologous and allogeneic bone marrow transplantation, and immunotherapy.
  • Outcomes varied: one patient died of disease, one achieved complete response but developed a secondary malignancy, and one remains alive with no evidence of disease.

Conclusions:

  • Syncytial variant histology may represent a poor prognostic factor in children diagnosed with Hodgkin lymphoma.
  • Further research is warranted to understand the specific behavior and optimal management of SV-HL in pediatric patients.

Keywords:
Hodgkin lymphomachildrennodular sclerosissyncytial variant

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