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Protein S deficiency in pregnancy
American Journal of Obstetrics and Gynecology
|July 1, 1986
Summary
Protein S deficiency, a rare cause of blood clots, requires careful management during pregnancy. This case highlights heparin therapy and pregnancy termination for a patient with recurrent venous thrombosis.
Area of Science:
- Reproductive Medicine
- Hematology
- Genetics
Background:
- Protein S deficiency is a rare inherited thrombophilia.
- Recurrent venous thromboembolism (VTE) during pregnancy poses significant risks.
Observation:
- A primigravid patient presented with a history of recurrent venous thrombosis.
- The patient was diagnosed with protein S deficiency.
Findings:
- Management involved prophylactic heparin therapy.
- Elective pregnancy termination was performed to mitigate thrombotic risk.
Implications:
- Protein S deficiency diagnosis may increase with broader assay use.
- This case underscores the importance of thrombophilia screening in pregnancy.
- Anticoagulation strategies are crucial for managing pregnancy in protein S deficient individuals.