Related Experiment Video
Updated: Feb 14, 2026

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
Sociodemographic, obstetric characteristics, antenatal morbidities, and perinatal depressive symptoms: A three-wave
Ying Lau1, Tha Pyai Htun1, Ho Keung Dennis Kwong2
1Department of Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Insights
Perinatal depressive symptoms peak in the second trimester. Unmarried status, unplanned pregnancy, gestational diabetes, and headache increase the risk for these symptoms.
Area of Science:
- Perinatal mental health
- Obstetrics
- Psychiatry
Background:
- Perinatal depressive symptoms affect maternal well-being.
- Understanding risk factors is crucial for timely intervention.
Purpose of the Study:
- Investigate the pattern of perinatal depressive symptoms.
- Determine relationships between sociodemographic, obstetric, and health factors and these symptoms using structural equation modeling (SEM).
Main Methods:
- A three-wave prospective longitudinal study of 361 women.
- Data collected during the second trimester, third trimester, and six weeks postpartum.
- Edinburgh Postnatal Depression Scale (EPDS) used for symptom assessment.
Main Results:
- Depressive symptom intensity was highest in the second trimester.
- Unmarried status, unplanned pregnancy, gestational diabetes, and headache were significantly associated with higher EPDS scores.
- Early depressive symptoms predicted later symptoms, with a well-fitting SEM.
Conclusions:
- Monitoring depressive symptoms in the second trimester is significant.
- Interventions targeting unmarried status, unplanned pregnancy, gestational diabetes, and headache can reduce perinatal depression risk.
Objectives:
This study aimed (1) to investigate the pattern of perinatal depressive symptoms, and (2) to determine the relationships between sociodemographic characteristics, obstetric factors, antenatal morbidities, postnatal conditions, and perinatal depressive symptoms using a structural equation model (SEM).
Method:
A three-wave prospective longitudinal design was used for 361 women in their second trimester, third trimester, and at six weeks postpartum. The Edinburgh Postnatal Depression Scale (EPDS) was used to assess the depressive symptoms.
Results:
The intensity of depressive symptoms was the highest in the second trimester among the three waves. The SEM showed that unmarried status, unplanned pregnancy, gestational diabetes, and headache were significantly associated with EPDS in the first and second waves. The EPDS in the first wave was able to predict the EPDS in the second and third waves. The SEM has satisfactorily fit with the data (chi-square/degree of freedom = 1.42, incremental fit index = 0.91, Tucker-Lewis index = 0.90, comparative fit index = 0.91, and root mean square error of approximation = 0.03).
Conclusion:
The findings highlight the significance of monitoring depressive symptoms in the second trimester. Findings from this study could be useful in the design of effective intervention among women with unmarried status, unplanned pregnancy, gestational diabetes, and headache in order to reduce risk of perinatal depressive symptoms.
Related Concept Videos
Long-term Depression
Long-term Depression
Calcium Ion Concentration Mechanism
If over...
Characteristics of Life
Freezing Point Depression and Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
Depressants
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
The Wave Nature of Light

