Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Behavior?00:54

What is Behavior?

10.3K
Behaviors are actions that an organism engages in—they can be related to finding food, reproducing, defending against threats, and many other possible actions. Behaviors include activities related to the environment around the animal—such as migration—as well as social interactions within a species or population. Many behaviors involve motor output—that is, muscle movements—while others involve less visible actions, such as learning.
10.3K
Responses to Heat and Cold Stress02:45

Responses to Heat and Cold Stress

14.9K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
14.9K
Responses to Salt Stress02:02

Responses to Salt Stress

14.7K
Salt stress—which can be triggered by high salt concentrations in a plant’s environment—can significantly affect plant growth and crop production by influencing photosynthesis and the absorption of water and nutrients.
14.7K
Natural Selection and Adaptation01:15

Natural Selection and Adaptation

1.5K
Natural selection, a fundamental concept in evolutionary biology, is the mechanism by which evolution is driven, favoring organisms that are best adapted to their environments. This process enhances their chances of survival and reproduction. Adaptation, a key outcome of this process, involves genetic modifications that optimize an organism's functionality under specific environmental challenges, such as extreme cold or thinner air at high altitudes.
Beyond physical adaptations,...
1.5K
Adaptability of Cytoskeletal Filaments01:12

Adaptability of Cytoskeletal Filaments

6.1K
The cytoskeleton is a complex dynamic structure performing varied functions based on cellular requirements. The adaptability of the individual filaments in the cytoskeleton determines their ability to perform various functions within the cell. It can undergo rapid reorganization during processes like cell division or remain stable for several hours as in the interphase. The adaptability of these filaments depends on stringent regulatory mechanisms. The microfilament and microtubules of the...
6.1K
Stress01:20

Stress

8.8K
When a force is applied on a body, it undergoes deformation. In order to restore the body to its original shape and/or size, an opposite or restoring force is generated within the body. This restoring force is equal to the magnitude of the applied force, but acts in the opposite direction. The amount of this restoring force developed per unit area of the body is called stress. Stress is a tensor quantity and has the SI unit pascal. Stress can be separated into four broad categories depending...
8.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inhibition of stress resilience and adult hippocampal neurogenesis by platelet-derived LPA16:0 in anxiety.

Nature communications·2026
Same author

Activity-dependent degradation of Kv4.2 contributes to synaptic plasticity and behavior in Angelman syndrome model mice.

Cell reports·2025
Same author

The curious interpretation of novel object recognition tests.

Trends in neurosciences·2025
Same author

Adult Neurogenesis and the Initiation of Social Aggression in Male Mice.

Hippocampus·2024
Same author

Using Zebrafish Embryos to Study Pharmacological Effects on Neural Development in Hands-On Neurobiology Laboratory Activities.

Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience·2024
Same author

Rewarded Maze Training Increases Approach Behavior in Rats Through Neurogenesis-Dependent Growth of Ventral Hippocampus-Prelimbic Circuits.

Biological psychiatry global open science·2023
Same journal

Neuroendocrine mechanisms of stress-induced KNDy-GnRH pulse generator suppression: Linking HPA-axis activation to female reproductive dysfunction.

Frontiers in neuroendocrinology·2026
Same journal

Aging-related autonomic nervous system imbalance and adrenergic regulation of immunity: Implications for inflammaging, autoimmunity, and long COVID.

Frontiers in neuroendocrinology·2026
Same journal

Neuroactive steroids as targets of micro- and nano-plastics: Putative impact on brain function and disease.

Frontiers in neuroendocrinology·2026
Same journal

Systems neuroendocrinology in ME/CFS and long COVID: a chronobiological framework for hormone-based research.

Frontiers in neuroendocrinology·2026
Same journal

N-methyl-d-aspartate receptor subunits interacting with regulators mediate neuropathic pain: from mechanisms to therapy.

Frontiers in neuroendocrinology·2026
Same journal

Mechanisms of photoperiodic polyphenism in vertebrates.

Frontiers in neuroendocrinology·2026
See all related articles

Related Experiment Video

Updated: Feb 14, 2026

Behavioral Approaches to Studying Innate Stress in Zebrafish
05:29

Behavioral Approaches to Studying Innate Stress in Zebrafish

Published on: May 1, 2019

9.7K

Behavioral and structural adaptations to stress.

Heather A Cameron1, Timothy J Schoenfeld1

  • 1Section on Neuroplasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.

Frontiers in Neuroendocrinology
|February 9, 2018
PubMed
Summary
This summary is machine-generated.

Stressful experiences alter brain structure and behavior, potentially as adaptive responses. New dentate gyrus neurons may improve adaptability, while hippocampal atrophy stabilizes behavior during chronic stress.

Keywords:
Adult neurogenesisBehavioral adaptationDendritesDentate gyrusHippocampusMorphologyStressVolume

More Related Videos

Chronic Stress Shifts Effort-Related Choice Behavior in a Y-Maze Barrier Task in Mice
09:37

Chronic Stress Shifts Effort-Related Choice Behavior in a Y-Maze Barrier Task in Mice

Published on: August 13, 2020

12.2K
Studying the Neural Basis of Adaptive Locomotor Behavior in Insects
10:19

Studying the Neural Basis of Adaptive Locomotor Behavior in Insects

Published on: April 13, 2011

13.3K

Related Experiment Videos

Last Updated: Feb 14, 2026

Behavioral Approaches to Studying Innate Stress in Zebrafish
05:29

Behavioral Approaches to Studying Innate Stress in Zebrafish

Published on: May 1, 2019

9.7K
Chronic Stress Shifts Effort-Related Choice Behavior in a Y-Maze Barrier Task in Mice
09:37

Chronic Stress Shifts Effort-Related Choice Behavior in a Y-Maze Barrier Task in Mice

Published on: August 13, 2020

12.2K
Studying the Neural Basis of Adaptive Locomotor Behavior in Insects
10:19

Studying the Neural Basis of Adaptive Locomotor Behavior in Insects

Published on: April 13, 2011

13.3K

Area of Science:

  • Neuroscience
  • Behavioral Science
  • Stress Research

Background:

  • Unpredictable stressors induce behavioral changes linked to depression and anxiety.
  • These stressors also cause structural alterations in the hippocampus, a key brain region for memory and emotion regulation.
  • Observed hippocampal changes include reduced adult neurogenesis and altered neuronal morphology.

Purpose of the Study:

  • To review the relationship between stress-induced behavioral and structural changes in the hippocampus.
  • To explore the adaptive significance of these neurobiological modifications.
  • To propose that hippocampal changes may represent adaptive mechanisms for coping with stress.

Main Methods:

  • Literature review and synthesis of existing research on stress, behavior, and hippocampal neurobiology.
  • Analysis of studies investigating adult neurogenesis and neuronal morphology in response to stress.
  • Conceptual framework development to interpret findings within an adaptive context.

Main Results:

  • Stressors significantly impact depression- and anxiety-related behaviors.
  • Hippocampal structural changes, such as decreased adult neurogenesis and altered dendritic morphology, are consistently observed following stress.
  • These changes, previously considered detrimental, may serve adaptive functions.

Conclusions:

  • New neurons in the dentate gyrus might enhance behavioral adaptability by biasing responses in novel situations based on prior stress exposure.
  • Atrophy-like changes and reduced neurogenesis in the hippocampus following chronic stress could limit stress responses and promote behavioral stability.
  • Hippocampal adaptations to stress may represent a strategy to optimize survival and function in challenging environments.