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Updated: Feb 14, 2026

High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages
Published on: August 11, 2014
[Salmonella enterica: an ally in the therapy of cancer]
Hilda Chávez-Navarro1, Daniel Dimitri Hernández-Cueto1, Ariel Vilchis-Estrada1
1Unidad de Investigación en Enfermedades Oncológicas, Hospital Infantil de México Federico Gómez, México D.F., México.
Abstract:
Salmonella enterica, a species of facultative anaerobic bacteria, has demonstrated success as a live-attenuated bacterial vector for vaccination. S. enterica has also demonstrated promise as a therapeutic agent against cancer. Pre-clinical and clinical trials have shown that S. enterica is localized in both solid and semi-solid tumors as well as in metastatic tumors. Moreover, S. enterica reduces resistance to treatment with other agents. In this review we present the novel therapeutic anti-cancer approaches that use S. enterica both for its ability as a delivery system for heterologous moieties against cancer and for its direct anti-cancer properties.
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