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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Primary Active Transport01:47

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In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps that are embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction...
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In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction they would...
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Vascular plants, which account for over 90% of the Earth’s vegetation, all undergo primary growth—which lengthens roots and shoots. Many land plants, notably woody plants, also undergo secondary growth—which thickens roots and shoots.
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Primary Production01:06

Primary Production

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The total amount of energy acquired by primary producers in an ecosystem is called gross primary production (GPP). However, of this energy, producers use some for metabolic processes, and some is lost as heat, decreasing the amount of energy available to the next trophic level. The remaining usable amount of energy is called the net primary productivity (NPP). In terrestrial ecosystems, NPP is driven by climate, while light penetration and nutrient availability drive NPP in aquatic ecosystems.
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Primary Distribution01:28

Primary Distribution

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Primary distribution systems deliver electrical power from substations to consumers through various voltage classes, with 15-kV class voltages being predominant among U.S. utilities. Older 2.5- and 5-kV classes are being replaced by 15-kV primaries, while higher 25- to 34.5-kV classes are used in high-density urban areas and rural regions with long feeders. Three-phase, four-wire multigrounded systems are widely employed for balanced power delivery, using the neutral wire as a grounding point.
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Related Experiment Video

Updated: Feb 14, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

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Primary immunodeficiencies and B-cell lymphomas.

María Anunciación Martín-Mateos1, Mónica Piquer Gibert1

  • 1Facultad de Medicina, Hospital Universitario Sant Joan de Déu, Universidad de Barcelona, Barcelona, Spain.

Boletin Medico Del Hospital Infantil De Mexico
|February 9, 2018
PubMed
Summary
This summary is machine-generated.

Common variable immunodeficiency (CVID) patients are at increased risk for Epstein-Barr virus (EBV)-associated lymphomas. Early detection of EBV infections and non-Hodgkin

Keywords:
Antitumor immunityB lymphomasCommon variable immunodeficiencyEpstein-Barr virusInmunidad antitumoralInmunodeficiencia variable comúnLinfoma no HodgkinLinfomas BNon-Hodgkin's lymphomaVirus Epstein-Barr

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Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
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Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
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Area of Science:

  • Immunology
  • Oncology
  • Virology

Background:

  • Primary immunodeficiencies, including Common Variable Immunodeficiency (CVID), impair anti-tumor defenses.
  • CVID is characterized by B lymphocyte differentiation defects, making patients susceptible to Epstein-Barr Virus (EBV) infection.
  • Uncontrolled proliferation of EBV-infected B lymphocytes can lead to lymphoma development in immunocompromised individuals.

Purpose of the Study:

  • To describe clinical cases of non-Hodgkin's lymphoma (NHL) in pediatric patients with CVID.
  • To highlight the association between EBV infection and lymphoma in CVID patients.
  • To evaluate treatment outcomes for NHL in this patient population.

Main Methods:

  • Retrospective analysis of 28 CVID patients diagnosed between 2000-2013 at University Hospital Sant Joan de Deu, Barcelona.
  • Detailed description of four pediatric patients (<18 years) who developed NHL, with EBV association noted in two cases.
  • Review of treatment regimens including rituximab monotherapy and CHOP chemotherapy with radiotherapy or rituximab.

Main Results:

  • Four pediatric patients with CVID developed non-Hodgkin's lymphoma (NHL).
  • EBV was associated with lymphoma in two of the four cases.
  • All four patients achieved complete remission with various treatment protocols, including rituximab and CHOP-based regimens.

Conclusions:

  • Early detection of EBV infections is crucial in CVID patients.
  • Prompt screening for non-Hodgkin's lymphoma (NHL) is recommended for all CVID patients, irrespective of age.
  • Timely diagnosis and appropriate treatment can lead to complete remission in EBV-associated lymphomas in CVID.