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Updated: Feb 14, 2026

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.6K

Evaluation of the TRPM2 channel as a biomarker in breast cancer using public databases analysis

Adriana Sumoza-Toledo1, Mario Iván Espinoza-Gabriel2, Dvorak Montiel-Condado3

  • 1Instituto de Investigaciones Médico-Biológicas, Universidad Veracruzana, Veracruz, Veracruz, Mexico.

Boletin Medico Del Hospital Infantil De Mexico
|February 9, 2018
PubMed
Abstract

Insights

Transient Receptor Potential Melastatin-2 (TRPM2) channel is overexpressed in breast cancer. Low TRPM2 expression predicts poor outcomes in certain breast cancer subtypes, suggesting its role as a prognostic biomarker.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biophysics

Background:

  • Breast cancer is a prevalent malignancy in women.
  • Ion channels play a significant role in cancer progression.
  • Transient Receptor Potential Melastatin-2 (TRPM2) is implicated in cell migration and death.

Purpose of the Study:

  • To investigate the prognostic value of TRPM2 in breast cancer.
  • To analyze TRPM2 expression patterns in breast carcinoma.
  • To evaluate TRPM2 as a potential biomarker for breast cancer aggressiveness.

Main Methods:

  • Analysis of public databases: Oncomine™ and Kaplan-Meier Plotter.
  • Investigated TRPM2 mRNA expression levels in breast cancer tissues.
  • Correlated TRPM2 expression with patient outcomes and coexpressed genes.

Main Results:

  • TRPM2 mRNA is significantly overexpressed in invasive and in situ breast carcinoma compared to normal tissue.
  • TRPM2 coexpression with genes involved in cellular migration, transformation, and apoptosis.
  • Low TRPM2 expression is associated with poor prognosis in ER- and HER2+ breast cancer patients.

Conclusions:

  • TRPM2 serves as a promising biomarker for breast cancer aggressiveness.
  • TRPM2 represents a potential therapeutic target for novel breast cancer treatments.
Keywords:
BiomarcadorBiomarkerBreast cancerCanal iónicoCáncer de mamaIon channelMicroarrayMicroarregloTRPM2

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