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Oral Biofilm Sampling for Microbiome Analysis in Healthy Children
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Urinary exoglycosidases, reference values in healthy children.

Beata Zalewska-Szajda1, Katarzyna Taranta-Janusz2, Sylwia Chojnowska3

  • 1Department of Imaging Diagnostics, Children's Clinical Hospital, Medical University of Bialystok, Bialystok, Poland.

Advances in Medical Sciences
|February 9, 2018
PubMed
Summary

Urinary lysosomal exoglycosidase activities, including alpha-fucosidase and beta-galactosidase, are highest in young children. These enzyme levels significantly decrease with age in healthy children and adolescents.

Keywords:
Lysosomal exoglycosidasesα-Fucosidase (FUC)α-Mannosidase (MAN)β-Galactosidase (GAL)β-Glucuronidase (GLU)

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Area of Science:

  • Biochemistry
  • Pediatrics
  • Clinical Chemistry

Background:

  • Lysosomal exoglycosidases play crucial roles in cellular metabolism.
  • Understanding age-related changes in enzyme activity is vital for pediatric health assessment.

Purpose of the Study:

  • To investigate the impact of age on urinary lysosomal exoglycosidase activities.
  • To establish reference values for alpha-fucosidase, beta-galactosidase, beta-glucuronidase, and alpha-mannosidase in pediatric populations.

Main Methods:

  • Urine samples analyzed from 203 healthy children and adolescents (6 months to 17.9 years).
  • Colorimetric methods used to quantify enzyme activities, normalized to creatine levels (pKat/μg Cr.).

Main Results:

  • Highest enzyme activities observed in children under 3 years old.
  • Significant negative correlation found between enzyme activities and age (p < 0.0001).
  • Percentile-based reference values established for enzyme activities across different age intervals.

Conclusions:

  • This study provides the first reference values for urinary exoglycosidase activities in children and adolescents.
  • Age-dependent reference ranges are crucial for accurate interpretation of these enzyme levels in pediatric diagnostics.