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Updated: Feb 14, 2026

3D Modeling of Dendritic Spines with Synaptic Plasticity
Published on: May 18, 2020
Deregulation of synaptic plasticity in autism
1Department of Neurobiology, University of Chicago, Chicago, IL 60637, USA.
Abstract:
A puzzling observation in the study of autism spectrum disorder (ASD) in mouse models has been the deregulation of long-term synaptic depression (LTD), a form of experience-dependent synaptic plasticity, across brain areas and across syndromic and non-syndromic forms of autism. This review attempts to approach this phenomenon from a largely, but not exclusively, cerebellar perspective. Three potential consequences of LTD deregulation are discussed that are relevant for ASD phenotypes: resulting impairment of proper developmental synaptic pruning, impairment of motor coordination and motor learning, and impairment of the processing of sensory input.
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