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Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
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Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
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The gastrointestinal (GI) tract, extending from the mouth to the anus, plays a pivotal role in the digestion and absorption of nutrients. This process involves both mechanical and chemical actions facilitated by various enzymes.
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Gastrointestinal Motility Monitor GIMM
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Phytotherapy in Functional Gastrointestinal Disorders.

Olaf Kelber1, Rudolf Bauer2, Wolfgang Kubelka3

  • 1Innovation and Development, Phytomedicines Supply and Development Center, Bayer Consumer Health Division, Steigerwald Arzneimittelwerk GmbH, Darmstadt, Germany.

Digestive Diseases (Basel, Switzerland)
|February 9, 2018
PubMed
Summary
This summary is machine-generated.

Phytotherapy, or herbal medicine, is a key treatment for functional gastrointestinal diseases (FGID). Rational combinations of herbs, like STW 5, offer proven, evidence-based options for managing FGID effectively.

Keywords:
Aromatic drugsBitter drugsCombination medicinesHerbal drugsHerbsInflammationSpasmolysis

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Area of Science:

  • Integrative Medicine
  • Pharmacognosy
  • Gastroenterology

Background:

  • Phytotherapy is a traditional and increasingly evidence-based approach for managing functional gastrointestinal diseases (FGID).
  • Diverse phytotherapeutic traditions exist globally, with some integrated into modern evidence-based medicine (EBM).

Purpose of the Study:

  • To highlight the significance of FGID as a primary indication in phytotherapy.
  • To illustrate how rational herbal combinations, supported by EBM, can be developed and validated.

Main Methods:

  • Classification of European herbs used for FGID based on active constituents and mechanisms (e.g., amara, aromatica, spasmolytics, anti-inflammatories).
  • Review of scientific evidence supporting the efficacy of specific herbal preparations in FGID.
  • Case example of STW 5, a multi-component herbal product, demonstrating clinical validation.

Main Results:

  • Functional gastrointestinal diseases (FGID) represent a major area of application for phytotherapy, both in Europe and Asia.
  • Herbs for FGID are categorized by their pharmacological actions, facilitating targeted treatment strategies.
  • Combination phytotherapy, exemplified by STW 5, can achieve high efficacy when components have complementary mechanisms.

Conclusions:

  • FGID are a leading indication for phytotherapy, with significant accumulated scientific evidence.
  • Rational, evidence-based herbal combinations are established therapeutic options for FGID.
  • Modern phytotherapy, particularly well-researched combinations, is an integral part of evidence-based medicine.