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Updated: Feb 14, 2026

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
Leucocyte- and platelet-rich fibrin block for bone augmentation procedure: A proof-of-concept study
Simone Cortellini1,2, Ana B Castro1,2, Andy Temmerman1,2
1Department of Oral Health Sciences, Section of Periodontology, KU Leuven, Leuven, Belgium.
Aim:
The objective of this proof-of-concept study was to investigate the effects of a new guided bone regeneration technique with a tissue engineering approach.
Materials And Methods:
This single cohort observational study evaluated the outcome of the leucocyte- and platelet-rich fibrin (L-PRF) Block for horizontal bone augmentation in the maxilla. The L-PRF Block is prepared by mixing a particulated biomaterial with chopped L-PRF membranes at a 50:50 ratio and adding liquid fibrinogen to glue all together. Horizontal augmentation was assessed linearly and volumetrically immediately after surgery and 5-8 months later by matching consecutive cone beam computed tomography (CBCTs).
Results:
Ten patients (mean age of 50.7 years [±17.2]) representing 15 sites with horizontal alveolar deficiencies were included. Superimposition of pre-operative and posthealing CBCT scans showed an average linear horizontal bone gain of 4.6 mm (±2.3), 5.3 mm (±1.2) and 4.4 mm (±2.3), measured at 2, 6 and 10 mm from the alveolar crest, respectively. The volumetric gain was 1.05 cm3 (±0.7) on average. The resorption rate after 5-8 months was 15.6% (±6.7) on average.
Conclusions:
L-PRF Block may be a suitable technique to augment deficient alveolar ridges.
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