Effect of spirometry on intra-thoracic pressures
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Updated: Feb 14, 2026

A Novel Non-invasive Method for the Detection of Elevated Intra-compartmental Pressures of the Leg
Published on: May 31, 2019
Nicholas B Tiller1,2, Andrew J Simpson3,4
1Academy of Sport and Physical Activity, Sheffield Hallam University, Sheffield, S10 2BP, UK. n.tiller@shu.ac.uk.
Objective:
Due to the high intra-thoracic pressures associated with forced vital capacity manoeuvres, spirometry is contraindicated for vulnerable patients. However, the typical pressure response to spirometry has not been reported. Eight healthy, recreationally-active men performed spirometry while oesophageal pressure was recorded using a latex balloon-tipped catheter.
Results:
Peak oesophageal pressure during inspiration was - 47 ± 9 cmH2O (37 ± 10% of maximal inspiratory pressure), while peak oesophageal pressure during forced expiration was 102 ± 34 cmH2O (75 ± 17% of maximal expiratory pressure). The deleterious consequences of spirometry might be associated with intra-thoracic pressures that approach maximal values during forced expiration.
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