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Updated: Feb 14, 2026

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
Published on: August 11, 2023
Angiogenesis and Fibrogenesis in Oral Submucous Fibrosis: A Viewpoint
Sheetal S Choudhari1, Deepak G Kulkarni2, Sangeeta Patankar3
1Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College & Hospital, Dr. D. Y. Patil Vidyapeeth, Pune Maharashtra, India, Phone: +919819331220,
Abstract:
Oral submucous fibrosis (OSF) is characterized by excessive fibrosis of submucosa. The degree of vascularity in OSF has always been a matter of debate. Angiogenesis is the key mechanism involved in regeneration and repair. It also plays an important role in various pathologic conditions. Angiogenesis may contribute to the progression of fibrosis in fibrotic disorders. Inhibition of pathological angiogenesis is considered to be a new strategy for the treatment of various fibrotic disorders. In OSF, angiogenesis can be related to progression fibrosis. This article briefly describes the role of angiogenesis in pathogenesis of fibrosis in OSF and the importance of inhibition of pathologic angiogenesis in its prevention and treatment.
Clinical Significance:
Understanding the association between angiogenesis and fibrogenesis can help in developing new therapeutic strategies for treatment of OSF.
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