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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
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Acute Renal Failure Adversely Affects Survival in Pediatric Dengue Infection
Biswanath Basu1, Birendranath Roy2
1Division of Pediatric Nephrology, Department of Pediatrics, NRS Medical College and Hospital, Kolkata, West Bengal, India.
Summary
Dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) significantly increase the risk of acute renal failure (ARF) in children. ARF in dengue patients leads to a high mortality rate.
Area of Science:
- Pediatrics
- Infectious Diseases
- Nephrology
Background:
- Dengue is a major mosquito-borne viral illness.
- Acute renal failure (ARF) is a severe complication in pediatric dengue cases.
Purpose of the Study:
- To compare baseline characteristics, outcomes, and risk factors in children with dengue, with and without renal failure (RF).
Main Methods:
- A retrospective cohort review was conducted.
- Patients with and without RF were compared based on clinical data.
Main Results:
- 13.4% of 97 children with dengue presented with RF.
- RF was associated with higher rates of dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) (100% vs 32%) and vasopressor support (70% vs 14%).
- The 7-day survival rate was significantly lower in the RF group (61.5%) compared to the non-RF group (96.4%).
Conclusions:
- DHF/DSS is an independent risk factor for ARF in dengue patients.
- Development of ARF in children with dengue is associated with a high mortality rate.
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