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Published on: January 14, 2014
Reversible Cerebral Vasoconstriction Syndrome due to Atovaquone
Takahiro Makino1, Ikuo Kamitsukasa1, Shoichi Ito2
1Department of Neurology, Chibaken Saiseikai Narashino Hospital, Narashino, Japan.
Abstract:
A 72-year-old Japanese woman with rheumatoid arthritis whose activity decreased with previous treatments had recurrent thunderclap headaches during an atovaquone regimen for the treatment of pneumocystis pneumonia. The recurrent headaches disappeared after discontinuation of the drug. Brain magnetic resonance images showed multiple cerebral vasoconstrictions of cerebral arteries with vasogenic cerebral white matter edema, which diminished several weeks later. We diagnosed the patient's headaches as reversible cerebral vasoconstriction syndrome due to atovaquone.
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