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Cathepsin G Is Expressed by Acute Lymphoblastic Leukemia and Is a Potential Immunotherapeutic Target
Maliha Khan1, Selena Carmona2, Pariya Sukhumalchandra2
1Department of Leukemia, MD Anderson Cancer Center, Houston, TX, United States.
Frontiers in Immunology
|February 10, 2018
Summary
Cathepsin G (CG) is widely expressed in acute lymphoid leukemia (ALL) and indicates a poor prognosis. This study shows CG is a potential immunotherapeutic target for ALL, with CG1-specific T cells effectively lysing patient ALL cells.
Area of Science:
- Immunology
- Oncology
- Molecular Biology
Background:
- Cathepsin G (CG) is a protease found in myeloid cells, previously identified as an immunogenic target in acute myeloid leukemia (AML).
- CG is highly expressed in AML blasts and leukemia stem cells.
Purpose of the Study:
- To investigate Cathepsin G (CG) expression levels in acute lymphoid leukemia (ALL).
- To evaluate CG as a potential immunotherapeutic target for ALL.
Main Methods:
- Reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting to detect CG mRNA and protein.
- Reverse-phase protein array (RPPA) analysis in a cohort of 130 ALL patients.
- In vitro studies using CG1-specific cytotoxic T lymphocytes.
Main Results:
- CG mRNA and protein were detected in B-ALL patient samples and cell lines.
- CG is widely expressed in ALL and associated with a poor prognosis.
- ALL cells can take up CG, and patient ALL cells were lysed by CG1-specific cytotoxic T lymphocytes in vitro.
Conclusions:
- Cathepsin G is highly expressed in acute lymphoid leukemia.
- CG represents a promising target for the development of novel immunotherapies for ALL.
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