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Related Experiment Videos

Decrease in helper (T4+) lymphocytes following cimetidine treatment for duodenal ulcer.

R Hast, P Bernell, R Befrits

    Clinical and Experimental Immunology
    |April 1, 1986
    PubMed
    Summary
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    Cimetidine treatment significantly reduced T4+ cells and the T4/T8 ratio in patients with duodenal ulcers. This immune modulation occurred in vivo but not in vitro, suggesting complex mechanisms.

    Area of Science:

    • Immunology
    • Pharmacology

    Background:

    • Cimetidine is a widely used medication for duodenal ulcers.
    • The in vivo effects of cimetidine on peripheral blood lymphocyte (PBL) subpopulations require further investigation.

    Purpose of the Study:

    • To investigate the in vivo influence of cimetidine on peripheral blood lymphocyte (PBL) subpopulations.
    • To assess changes in T cell subsets and their ratios during cimetidine therapy.

    Main Methods:

    • Monoclonal antibodies (MoAb) were used to define PBL subpopulations.
    • Eight patients with uncomplicated duodenal ulcers were studied before, during, and after cimetidine treatment.

    Main Results:

    • A significant decrease in T3+ and T4+ cells was observed after 3-5 weeks of cimetidine.

    Related Experiment Videos

  • The T4/T8 ratio significantly reduced due to decreased T4+ cells and the emergence of a new lymphocyte subpopulation.
  • Total lymphocyte and monocyte counts, and B1+ lymphocyte percentages remained unchanged.

    • Conclusions:

    • Cimetidine administration in vivo alters peripheral blood T cell subset proportions, notably reducing T4+ cells and the T4/T8 ratio.
    • The observed immunomodulatory effect does not appear to be a direct receptor-modulating effect of cimetidine on lymphocytes in vitro.