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Establishing Reference Ranges of Hematological Parameters from Malian Healthy Adults
Journal of Blood & Lymph
|February 10, 2018
Summary
This study establishes reference ranges for immuno-hematological parameters in healthy Malian adults, revealing differences from universal ranges. These findings are crucial for accurate diagnosis and treatment in regions lacking established local data.
Area of Science:
- Hematology
- Immunology
- Public Health
Background:
- Immuno-hematological parameters are vital for diagnosing and monitoring diseases.
- Established parameter ranges are lacking in many developing countries, hindering patient care.
- This study addresses this gap by defining ranges for Malian adults.
Purpose of the Study:
- To determine reference ranges for immuno-hematological parameters in healthy Malian adults.
- To compare these ranges with globally established values.
- To provide a basis for improved diagnostics in West Africa.
Main Methods:
- A cross-sectional study was conducted with 213 healthy Malian volunteers (18-59 years).
- Immuno-hematological parameters were measured.
- Median and percentile ranges (2.5-97.5) were calculated.
Main Results:
- Malian adults exhibited distinct ranges for parameters like white blood cell count, red blood cell count, hemoglobin, and platelet count compared to universal standards.
- Significant gender differences were observed in red blood cell count, hemoglobin levels (higher in males), and mean platelet volume (lower in males).
- Hemoglobin levels in West African populations show regional variations.
Conclusions:
- The established ranges can aid physicians in identifying hematological abnormalities in Malian patients.
- These findings may inform the definition of new normal hematological values for the Malian and broader West African populations.
- This research supports the development of more accurate, localized diagnostic tools.
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