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Updated: Feb 14, 2026

Preparation of High-Temperature Sample Grids for Cryo-EM
Published on: July 26, 2021
The 2017 Nobel Prize in Chemistry: cryo-EM comes of age
1Department of Biochemistry, University of Utah, Salt Lake City, UT, 84112, USA. peter.shen@biochem.utah.edu.
Abstract:
The 2017 Nobel Prize in Chemistry was awarded to Jacques Dubochet, Joachim Frank, and Richard Henderson for "developing cryo-electron microscopy (cryo-EM) for the high-resolution structure determination of biomolecules in solution." This feature article summarizes some of the major achievements leading to the development of cryo-EM and recent technological breakthroughs that have transformed the method into a mainstream tool for structure determination.
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