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[Progress in fungal polyketide biosynthesis].

Xiwei Chen1, Meng Xu1, Cheng Feng1

  • 1Institute of Modern Biopharmaceuticals, School of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.

Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology
|February 10, 2018
PubMed
Summary
This summary is machine-generated.

This review summarizes fungal polyketide biosynthesis, detailing enzyme mechanisms in highly-reducing polyketide synthases (HR-PKSs) and non-reducing polyketide synthases (NR-PKSs). Understanding these pathways aids in discovering novel fungal compounds and gene clusters.

Keywords:
biosynthesisenzymatic catalysisfungal polyketidegene clusternatural products

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Natural Products Chemistry

Background:

  • Fungal polyketides are complex molecules with diverse biological activities.
  • Their biosynthesis involves intricate, novel enzyme-catalyzed reactions.
  • Understanding these pathways is crucial for natural product discovery.

Purpose of the Study:

  • To review recent advances in the molecular mechanisms of fungal polyketide biosynthesis.
  • To cover various polyketide synthase (PKS) types, including hybrids.
  • To guide the discovery of new fungal polyketide natural products and analogues.

Main Methods:

  • Literature review of recent research on fungal polyketide biosynthesis.
  • Focus on molecular mechanisms of highly-reducing PKSs (HR-PKSs) and non-reducing PKSs (NR-PKSs).
  • Examination of hybrid PKS-NRPS and HR-NR PKS systems.

Main Results:

  • Elucidation of biosynthetic pathways for numerous fungal polyketides.
  • Detailed understanding of enzyme functions in HR-PKSs, NR-PKSs, and hybrid systems.
  • Identification of key reactions driving polyketide structural diversity.

Conclusions:

  • The study provides a comprehensive overview of fungal polyketide biosynthetic mechanisms.
  • Elucidated mechanisms facilitate the discovery of novel polyketide natural products.
  • This knowledge aids in identifying new gene clusters and designing analogues with desired properties.