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BioMEMS and Cellular Biology: Perspectives and Applications
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Hydrogel formulations for biologicals: current spotlight from a commercial perspective
Ludger M Ickenstein1, Patrick Garidel1
1Boehringer Ingelheim Pharma GmbH & Co. KG, Innovation Unit, Biologicals Development Germany, D-88397 Biberach an der Riss, Germany.
Therapeutic Delivery
|February 10, 2018
Summary
Hydrogels offer easy production for sustained release of potent immunoglobulins. However, current hydrogels have limited capacity and short release times, necessitating novel depot formulations for extended therapeutic effects.
Area of Science:
- Biomaterials Science
- Pharmaceutical Technology
- Drug Delivery Systems
Background:
- Hydrogels are attractive for sustained release of potent immunoglobulins due to ease of production.
- These formulations can reduce dosing frequency and maintain therapeutic drug concentrations.
- Limitations include restricted loading capacities and rapid release of hydrophilic immunoglobulins (hours to days).
Purpose of the Study:
- To explore desirable properties for novel hydrogel formulations.
- To discuss the use of established versus new excipients in hydrogel development.
- To present examples of biological hydrogel formulations in clinical development.
Main Methods:
- Review of hydrogel properties for sustained release.
- Analysis of excipient choices for biologicals.
- Compilation of clinical development examples for hydrogel-based biologicals.
Main Results:
- Hydrogels offer commercial advantages for immunoglobulin delivery.
- Current limitations necessitate advancements in hydrogel technology for longer-acting formulations.
- Several hydrogel formulations for biologicals have advanced to clinical trials.
Conclusions:
- There is a significant medical need for improved hydrogel depot formulations for immunoglobulins.
- Further research into hydrogel properties and excipients is crucial for developing long-term release systems.
- Clinical development examples highlight progress in this field, but further innovation is required.
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