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OCT-guided management of subclinical recurrent retinoblastoma
Marie-Claire Gaillard1, Susan Houghton1, Christina Stathopoulos1
1a Department of Ophthalmology, University of Lausanne , Jules-Gonin Eye Hospital, Fondation Asile des Aveugles , Lausanne , Switzerland.
Purpose:
Retinoblastoma (Rb) tumor recurrence in the papillary or macular region is a threat to life and visual prognosis respectively, making early detection indispensable. This study demonstrates the value of optical coherence tomography (OCT) in the early detection of subclinical tumor recurrence.
Methods:
Since June 2012, hand-held SD-OCT (spectral domain Optical Coherence Tomography) of retro-equatorial foci, the optic head nerve and macula, is systematically performed under anesthesia in children treated and followed for Rb.
Results:
Between June 2012 and January 2017, 16 subclinical recurrent tumors in 14 children were detected only by OCT in flat pigmented scars (n = 9), in type 2 regression (n = 3), on the optic nerve head (n = 3), and as secondary retinal seeding (n = 1).
Conclusion:
OCT has become invaluable in the modern management of Rb. It allows not only early detection of a lesion before any tumor extension towards the macula or optic nerve head, but also the monitoring of the therapeutic response.
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