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Related Experiment Video

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Human brain trauma severity is associated with lectin complement pathway activation.

Daiana De Blasio1, Stefano Fumagalli1, Franca Orsini1

  • 11 IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|February 10, 2018
PubMed
Summary
This summary is machine-generated.

The lectin pathway of complement is present in human traumatic brain injury (TBI) contusions. Its components correlate with injury severity, suggesting a key role in TBI pathophysiology.

Keywords:
MBL-associated serine proteasesTraumatic brain injurycomplement systemlectin complement pathwayneuroinflammation

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Area of Science:

  • Immunology
  • Neuroscience
  • Pathophysiology

Background:

  • The lectin pathway of complement plays a role in inflammatory responses.
  • Its involvement in traumatic brain injury (TBI) pathophysiology is not well understood in humans.

Purpose of the Study:

  • To investigate the presence and role of the lectin pathway in human TBI.
  • To correlate lectin pathway component levels with TBI severity.

Main Methods:

  • Brain samples from 28 TBI patients and 5 non-TBI controls were analyzed.
  • Imaging and immunoassays were used to detect lectin pathway molecules (MBL, ficolins, MASPs, C3 fragments, TCC).

Main Results:

  • Lectin pathway components were found in TBI contusions but not in normal brain parenchyma (except ficolin-1).
  • Levels of MBL, ficolin-2, ficolin-3, C3 fragments, and TCC were significantly elevated in TBI samples.
  • MASP-2 levels correlated with indicators of TBI severity.

Conclusions:

  • This study demonstrates the presence of lectin pathway components in human TBI.
  • The findings suggest a significant role for the lectin pathway in TBI pathophysiology and its association with injury severity.