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Microbiota regulate the development and function of the immune cells.

Qing Yu1, Anna Jia1, Yan Li1

  • 1a Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education , Institute of Cell Biology, College of Life Sciences, Beijing Normal University , Beijing , China.

International Reviews of Immunology
|February 10, 2018
PubMed
Summary
This summary is machine-generated.

The gut microbiota interacts with the host immune system, influencing immune cell development and function both locally and systemically. This intricate relationship offers potential therapeutic strategies for various diseases.

Keywords:
Immune-associate diseasesimmune cellsmechanismsmicrobiotamucosanonmucosa

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Area of Science:

  • Immunology
  • Microbiology
  • Host-Microbe Interactions

Background:

  • The human body hosts a complex microbiota, a community of microbes that co-evolve with the immune system.
  • There is a dynamic, mutualistic relationship between the host immune system and the microbiota.
  • Microbiota influences immune cell development and function, while immune cells shape microbial populations.

Purpose of the Study:

  • To explore the multifaceted interactions between the microbiota and the host immune system.
  • To elucidate the mechanisms by which microbiota impacts immune responses both locally and systemically.
  • To highlight the therapeutic potential of understanding microbiota-immune system crosstalk.

Main Methods:

  • Review of existing experimental data and scientific literature.
  • Analysis of mechanisms of microbiota influence on immune cells at mucosal and non-mucosal sites.
  • Investigation of molecular pathways, including chromatin remodeling (histone acetylation, DNA methylation).

Main Results:

  • Microbiota and microbial products directly modulate immune cells at mucosal sites, inducing effector molecules like cytokines.
  • Microbial products influence key signaling pathway factors.
  • Microbiota regulates immune cell development and function at non-mucosal sites through epigenetic modifications.

Conclusions:

  • The microbiota exerts both local and systemic effects on the immune system.
  • Understanding microbiota-immune interactions is crucial for developing novel immunotherapies.
  • Targeting the gut microbiota presents a promising avenue for disease prevention and treatment.