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Updated: Feb 14, 2026

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
Published on: October 27, 2020
Direct Splanchnic Perfusion Safely Avoids Deep Hypothermia
Muhammad Aanish Raees1, David P Bichell2
1Division of Pediatric Cardiac Surgery, Vanderbilt University Medical Center, Children's Hospital, Nashville, TN, USA..
Abstract:
Deep hypothermia for the operative correction of congenital cardiac lesions protects hypoperfused organs, mostly because of its effect on lowering metabolic demand and oxygen requirement. Deleterious cerebral and extracranial side effects of deep hypothermia itself calls for a reexamination of the therapeutic value of hypothermia, and has led to the development of alternative perfusion strategies. Here we describe the potential advantages of milder hypothermia over deep hypothermia and our method of a practical and reproducible implementation of multisite perfusion under mild hypothermia (32°C).
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