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Murine Model of Wound Healing
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Nanoengineered injectable hydrogels for wound healing application.

Giriraj Lokhande1, James K Carrow1, Teena Thakur1

  • 1Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, United States.

Acta Biomaterialia
|February 10, 2018
PubMed
Summary
This summary is machine-generated.

Injectable nanoengineered hemostats combining kappa-carrageenan and nanosilicates enhance wound healing. This system offers tunable mechanical properties and sustained therapeutic delivery for improved tissue regeneration and hemostasis.

Keywords:
HemostasisKappa-carrageenanNanocomposite hydrogelsTherapeutic releaseTwo-dimensional nanoparticlesWound healing

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Nanotechnology

Background:

  • Hemorrhage from wounds and surgical interventions poses a significant mortality risk.
  • Current hemostatic agents often lack the necessary bioactivity and delivery capabilities for optimal tissue repair.
  • There is a critical need for advanced injectable materials that can control bleeding and promote healing.

Purpose of the Study:

  • To develop injectable nanoengineered hemostats for enhanced wound healing and tissue regeneration.
  • To create a multifunctional nanocomposite hydrogel system with tunable mechanical properties.
  • To investigate the potential of this system as a vehicle for sustained therapeutic delivery.

Main Methods:

  • Fabrication of injectable hydrogels using kappa-carrageenan (κCA) and 2D nanosilicates.
  • Characterization of hydrogel properties, including shear-thinning behavior, mechanical stiffness, porosity, and protein adsorption.
  • Evaluation of hemostatic efficacy, cell adhesion, spreading, and platelet binding.
  • Assessment of sustained release of therapeutic biomacromolecules, specifically vascular endothelial growth factor (VEGF).

Main Results:

  • Injectable κCA/nanosilicate nanocomposite hydrogels exhibit tunable mechanical stiffness (20–200 kPa) and high porosity.
  • The hydrogels demonstrate enhanced protein adsorption, cell adhesion, and platelet binding.
  • Hemostatic efficacy was improved, with a two-fold acceleration in clotting time.
  • Sustained release of VEGF was achieved, promoting in vitro tissue regeneration and wound healing.

Conclusions:

  • The developed nanoengineered hydrogels serve as effective injectable hemostats.
  • These multifunctional materials facilitate enhanced wound healing and tissue regeneration through improved hemostasis and sustained therapeutic delivery.
  • The tunable nature and injectable form factor make them promising for minimally invasive approaches in treating penetrating injuries and surgical bleeding.