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IgE in lupus pathogenesis: Friends or foes?
Jean-François Augusto1, Marie-Elise Truchetet2, Nicolas Charles3
1CRCINA, INSERM, Université de Nantes, Université d'Angers, LabEx IGO, 49000 Angers, France; Service de Néphrologie-Dialyse-Transplantation, CHU Angers, 49000 Angers, France.
Autoimmunity Reviews
|February 10, 2018
Summary
Immunoglobulin E (IgE) plays a complex role in systemic lupus erythematosus (SLE), influencing autoantibody production and interferon-alpha (IFN-α) secretion by immune cells. This review explores IgE
Area of Science:
- Immunology
- Autoimmunity
- Molecular Biology
Background:
- Systemic lupus erythematosus (SLE) is a complex autoimmune disease.
- Emerging evidence suggests a role for Immunoglobulin E (IgE) in SLE pathophysiology.
- Conflicting data exist regarding IgE's precise function in SLE.
Purpose of the Study:
- To review and synthesize recent literature on IgE in SLE.
- To reconcile disparate findings on IgE's role in SLE.
- To propose new conceptual frameworks for understanding IgE in SLE.
Main Methods:
- Literature review of recent studies on IgE and SLE.
- Analysis of data from lupus mouse models (Lyn-/- and FcγIIB-/-.Yaa).
- Examination of IgE's effects on basophils, T helper 2 (Th2) cells, plasma cells, and plasmacytoid dendritic cells (pDCs).
Main Results:
- Autoreactive IgE activates basophils, promotes Th2 environments, and drives autoantibody production in mouse models.
- Autoreactive IgE, in synergy with IgG, enhances interferon-alpha (IFN-α) production by human pDCs.
- Non-autoreactive IgE may have a protective effect by reducing IFN-α secretion from pDCs.
Conclusions:
- IgE has a multifaceted role in SLE, with autoreactive IgE generally promoting disease.
- Further research is needed to fully elucidate the complex interactions of IgE in SLE pathogenesis.
- Reconciling the dual roles of IgE may offer new therapeutic strategies for SLE.
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