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Salidroside provides neuroprotection by modulating microglial polarization after cerebral ischemia

Xiangrong Liu1,2, Shaohong Wen1,2, Feng Yan2,3

  • 1China-America Institute of Neuroscience, Xuanwu Hospital of Capital Medical University, Beijing, 100053, People's Republic of China.

Journal of Neuroinflammation
|February 11, 2018
PubMed
Abstract

Insights

Salidroside (SLDS) reduces brain damage and improves function after stroke by shifting microglia from a pro-inflammatory (M1) to an anti-inflammatory (M2) state. This modulation promotes oligodendrocyte differentiation and neuronal survival, offering new therapeutic avenues.

Area of Science:

  • Neuroscience
  • Immunology
  • Pharmacology

Background:

  • Microglia play crucial roles in stroke pathology, exhibiting pro-inflammatory (M1) or anti-inflammatory (M2) phenotypes.
  • Salidroside (SLDS) is recognized for its anti-inflammatory and neuroprotective properties, but its specific mechanisms in stroke remain unclear.

Purpose of the Study:

  • To investigate the effects of Salidroside (SLDS) on neuroprotection and microglial polarization following stroke.

Main Methods:

  • Male C57/BL6 mice underwent focal cerebral ischemia and received intravenous SLDS.
  • Microglial polarization was assessed using RT-PCR and immunostaining.
  • Coculture systems evaluated SLDS-induced microglial effects on oligodendrocytes and neurons.

Main Results:

  • SLDS significantly decreased cerebral infarct volume and improved neurological outcomes.
  • SLDS treatment promoted a shift from M1 to M2 microglial polarization, enhancing phagocytosis and reducing inflammatory cytokines.
  • SLDS-treated microglia supported oligodendrocyte differentiation and protected neurons from oxygen-glucose deprivation.

Conclusions:

  • Salidroside (SLDS) demonstrates neuroprotective effects against cerebral ischemia by modulating microglial polarization towards an M2 phenotype.
  • Understanding SLDS-driven microglial polarization mechanisms may reveal novel therapeutic strategies for stroke treatment.
Keywords:
InflammationMicrogliaNeuronOligodendrocytePolarizationSalidrosideStroke

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