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Updated: Feb 14, 2026

Separation and Fractionation of Culture Filtrate Proteins (CFPs) from Mycobacterium tuberculosis

Separation and Fractionation of Culture Filtrate Proteins (CFPs) from Mycobacterium tuberculosis

Published on: July 11, 2025

Point of care diagnostics for tuberculosis.

A L García-Basteiro¹, A DiNardo², B Saavedra³

¹Centro de Investigação em Saúde de Manhiça, Maputo, Mozambique; Amsterdam Institute for Global Health and Development (AIGHD), Amsterdam, The Netherlands; ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clínic - Universitat de Barcelona, Rossello 132, 08036 Barcelona, Spain.

|February 11, 2018

Summary

New diagnostic tools are crucial for the End TB strategy

Keywords:

Diagnosis LAM NAATs Point-of-care Target product profile Tuberculosis Xpert

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Last Updated: Feb 14, 2026

Separation and Fractionation of Culture Filtrate Proteins (CFPs) from Mycobacterium tuberculosis

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Published on: July 11, 2025

Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test

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Published on: April 9, 2012

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

Published on: August 11, 2008

Area of Science:

Global health
Infectious diseases
Medical diagnostics

Background:

The End TB strategy aims for a 90% reduction in tuberculosis (TB) incidence and a 95% mortality reduction by 2035.
Achieving these goals necessitates novel diagnostic tools for timely TB detection.
Current diagnostic limitations hinder effective implementation at the point of care (POC).

Purpose of the Study:

To highlight the urgent need for improved point-of-care (POC) diagnostic tests for tuberculosis (TB).
To discuss recent advancements and existing limitations in TB diagnostic tools.
To emphasize the necessity for further research and development in POC diagnostics to find missed TB cases.

Main Methods:

Review of current tuberculosis diagnostic technologies and their limitations.
Analysis of the diagnostic test development pipeline for point-of-care applications.
Discussion of strategies for implementing existing tools and developing new ones.

Main Results:

Recent advancements include WHO-endorsed tests like Xpert MTB/RIF, Xpert MTB/RIF Ultra, TB-LAMP, and lateral flow LAM.
Existing POC diagnostic tests have limitations that require further improvement for optimal use.
Significant gaps exist in the current pipeline for developing new POC TB diagnostic tests.

Conclusions:

New tools are essential to meet the End TB strategy's ambitious goals.
Improved implementation of current diagnostics and development of novel POC tests are critical.
Addressing the "missed TB cases" requires continued research and innovation in diagnostics.