Related Experiment Video
Updated: Feb 14, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
Published on: February 9, 2011
Topical therapy for refractory rhinosinusitis caused by methicillin-resistant Staphylococcus aureus: First report in
Alan H Shikani1, Nadim Khoueir1, Mary Ann Jabra-Rizk2
1Department of Otolaryngology Head and Neck Surgery/Maryland Nose & Sinus Center at MedStar Union Memorial Hospital, Baltimore, MD, United States.
Objective:
The incidence of refractory chronic rhinosinusitis (CRS) associated with methicillin-resistant Staphylococcus aureus (MRSA) is rising and remains a therapeutic challenge. The goal of this study is to demonstrate the efficacy of a non-invasive topical therapy against MRSA in these patients.
Methods:
Seventeen patients with refractory CRS caused by MRSA were treated with a topical therapy protocol. Treatment consisted of weekly endoscopic sinus debridement followed by intra-sinus installation of a hydroxyl-ethylcellulose gel that releases mometasone and a culture-directed antibiotic for a period of 6 weeks, along with daily nasal nebulization of mometasone with the same antibiotic and saline rinses. Clinical outcome was assessed using the Lund-Kennedy (LK) symptom and endoscopic appearance scores. Sinus mucosal tissue was homogenized and cultured, and microbial biofilm burden was assessed based on colony forming units (CFUs) counts.
Results:
Rhinotopic therapy resulted in clearance of MRSA in 13 of 16 patients (81.2%). Treated patients also demonstrated significant improvement clinically as measured by the LK scores. In addition, a significant decrease in mucosal CFUs was observed post-therapy.
Conclusion:
Our findings demonstrate that topical therapy is an effective method for treating MRSA-associated refractory CRS.
More Related Videos
Related Concept Videos
Resistors In Series
In a series circuit, the...
Series Resonance
Data Reporting and Recording
Resistivity
Resistance
Series and Parallel Capacitors
First, consider capacitors connected in series to a battery. In this configuration, the plate connected to the battery's positive terminal develops a positive charge, while the plate attached to the negative terminal becomes negatively charged. An equal magnitude of charge is induced on the...

