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Related Experiment Video

Updated: Feb 14, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
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Prenatal Maternal Depressive Symptoms Predict Early Infant Health Concerns.

S S Coburn1,2, L J Luecken3, I A Rystad3

  • 1Department of Psychology, Arizona State University, Tempe, AZ, USA. scoburn@childrensnational.org.

Maternal and Child Health Journal
|February 11, 2018
PubMed
Summary

Prenatal depressive symptoms in mothers are linked to infant physical health concerns shortly after birth. Early intervention during pregnancy is crucial for infant well-being.

Keywords:
HealthInfantMotherPrenatal depression

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Area of Science:

  • Perinatal mental health
  • Infant health outcomes
  • Health disparities research

Background:

  • Health disparities in low-SES and ethnic minority populations may stem from prenatal and early life exposures.
  • Maternal postpartum depressive symptoms are linked to poorer infant health, but prenatal depression's impact on infant health is less understood.

Purpose of the Study:

  • To investigate if prenatal depressive symptoms predict infant physical health concerns at 12 weeks of age.
  • To determine if these associations persist beyond concurrent maternal depressive symptoms.
  • To examine potential mediating roles of birth weight, gestational age, and breastfeeding.

Main Methods:

  • Prospective study of 322 low-income Mexican American mothers and their infants.
  • Maternal surveys administered during pregnancy and 12 weeks postpartum.
  • Analysis of prenatal depressive symptoms' prediction of infant physical health concerns.

Main Results:

  • Higher prenatal depressive symptoms were significantly associated with more infant physical health concerns at 12 weeks (p < .001).
  • This association remained after controlling for 12-week maternal depressive symptoms, birth weight, gestational age, and breastfeeding.
  • Concurrent 12-week maternal depressive symptoms also correlated with infant health concerns (p < .01).

Conclusions:

  • Prenatal depressive symptoms are linked to increased infant health risks soon after birth.
  • The prenatal period is a critical window for infant health, highlighting the need for antenatal depression interventions.
  • Interventions during pregnancy may mitigate risks for adverse infant health outcomes.