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Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in Patients

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Published on: February 7, 2021

Deep coma does not always predict poor outcomes among patients with polytrauma.

Jen-Fu Huang¹, Chun-Hsiang Ou Yang¹, Chih-Yuan Fu²

¹Division of Trauma and Emergency Surgery, Chang Gung Memorial Hospital, 5 Fu-Xing Street, Guishan District, Taoyuan City, Taiwan, Republic of China.

European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society

|February 11, 2018

Summary

Polytrauma patients with a Glasgow Coma Scale (GCS) of 3 have a poor prognosis, but aggressive resuscitation can improve survival. Young patients responding well to resuscitation show better functional recovery.

Keywords:

Coma Glasgow Coma Scale Mortality Multiple trauma Recovery of function Traumatic brain injuries

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Area of Science:

Emergency Medicine
Trauma Surgery
Neurocritical Care

Background:

Polytrauma patients with a Glasgow Coma Scale (GCS) of 3 represent a critical subgroup with significant mortality.
Understanding prognostic factors is crucial for optimizing emergency department (ED) management and resource allocation.

Purpose of the Study:

To clarify the prognosis of polytrauma patients presenting to the ED with a GCS of 3.
To identify factors associated with survival and functional recovery in this patient population.

Main Methods:

Retrospective review of a trauma registry from January 2011 to December 2015.
Analysis of 145 polytrauma patients presenting with a GCS of 3.
Comparison of surviving and non-surviving patients to determine prognostic factors for survival and discharge GCS > 13.

Main Results:

Mortality rate was high (82.1%), with 119 of 145 patients not surviving.
Independent predictors of survival included the absence of bilateral dilated and fixed pupils and a GCS > 3 after resuscitation.
Independent predictors for a discharge GCS > 13 were age under 40 and a GCS > 3 after resuscitation.

Conclusions:

Aggressive resuscitation benefits polytrauma patients with a GCS of 3, particularly those showing a rapid response.
Younger patients with severe traumatic brain injury (GCS of 3) have a higher likelihood of functional recovery following ED resuscitation.