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Association of MTHFR gene polymorphisms with migraine in North Indian population

Sukhvinder Kaur1, Arif Ali2, Anil Kumar Pandey3

  • 1Department of Biosciences, UGC-PDF, Gene Expression Lab, Jamia Millia Islamia, New Delhi, India. singhrp12@rediffmail.com.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|February 11, 2018
PubMed

Insights

Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms are linked to migraine susceptibility. The A1298C CC genotype is a risk factor for migraine, while C677T influences migraine with aura.

Area of Science:

  • Genetics
  • Neurology
  • Molecular Biology

Background:

  • Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene are associated with elevated homocysteine levels, particularly with insufficient dietary folate.
  • These MTHFR gene variations are implicated as risk factors for complex neurovascular disorders, including migraine.

Purpose of the Study:

  • To investigate the association between MTHFR gene polymorphisms (C677T and A1298C) and the susceptibility to migraine.
  • To differentiate the impact of these polymorphisms on migraine with aura (MA) and migraine without aura (MO).

Main Methods:

  • A case-control study involving 100 migraine patients and 100 age- and sex-matched healthy controls.
  • Genotyping of MTHFR gene polymorphisms (C677T; rs 1801133, A1298C; rs 1801131) was performed using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) technique.
  • Genotypic and allelic frequencies were analyzed using SPSS version 24.

Main Results:

  • The CC genotype of the A1298C single nucleotide polymorphism (SNP) was significantly more frequent in migraine patients compared to controls (30% vs. 17%, p < 0.05).
  • The 677CT genotype and T allele of the C677T SNP were associated with an increased susceptibility to migraine with aura (MA) (p < 0.05).
  • No significant association was found between C677T polymorphisms and migraine without aura (MO), nor between A1298C polymorphisms and MA.

Conclusions:

  • The A1298C CC genotype may serve as a risk factor for overall migraine susceptibility.
  • Specific MTHFR polymorphisms, particularly the C677T variant, appear to influence susceptibility to migraine with aura.
  • Further research is warranted to elucidate the precise mechanisms linking MTHFR gene variations to different migraine subtypes.
Keywords:
MTHFR geneMigraineSingle nucleotide polymorphismsrs 1801131rs 1801133

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