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Exploration into Uric and Cardiovascular Disease: Uric Acid Right for heArt Health (URRAH) Project, A Study Protocol
Giovambattista Desideri1, Agostino Virdis2, Edoardo Casiglia3
1Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Insights
Serum uric acid levels are increasingly recognized as a cardiovascular risk factor. The URRAH project aims to identify the specific uric acid threshold that independently elevates cardiovascular disease risk in the general population.
Area of Science:
- Cardiology
- Metabolic Disorders
- Nephrology
Background:
- Elevated serum uric acid is a growing concern as a cardiovascular risk factor.
- Its direct or synergistic detrimental effects on cardiovascular health are increasingly evident.
- The precise threshold for serum uric acid contributing to cardiovascular risk remains undefined.
Purpose of the Study:
- To clarify and quantify the serum uric acid threshold associated with cardiovascular risk.
- To integrate this threshold into cardiovascular risk stratification algorithms.
- To inform prevention and management strategies for cardiovascular and cardio-nephro-metabolic disorders.
Main Methods:
- The Uric acid Right for heArt Health (URRAH) project is designed for this investigation.
- Focus on a broad, representative sample of the general Italian population.
- Primary objective: define the level of uricemia indicating significantly increased independent cardiovascular disease risk.
Main Results:
- Epidemiological studies are heterogeneous, with varying proposed cardiovascular thresholds.
- Preliminary data suggest cardiovascular thresholds differ from gout attack cut-offs.
- The URRAH project seeks to establish a definitive threshold for risk discrimination.
Conclusions:
- Identifying the specific serum uric acid threshold is critical for accurate cardiovascular risk assessment.
- This knowledge will enable targeted interventions and improved patient outcomes.
- The URRAH project is pivotal in elucidating the link between uricemia and cardiovascular health.
Abstract:
The relevance of cardiovascular role played by levels of serum uric acid is dramatically growing, especially as cardiovascular risk factor potentially able to exert either a direct deleterious impact or a synergic effect with other cardiovascular risk factors. At the present time, it still remains undefined the threshold level of serum uric acid able to contribute to the cardiovascular risk. Indeed, the available epidemiological case studies are not homogeneous, and some preliminary data suggest that the so-called "cardiovascular threshold limit" may substantially differ from that identified as a cut-off able to trigger the acute gout attack. In such scenario, there is the necessity to clarify and quantify this threshold value, to insert it in the stratification of risk algorithm scores and, in turn, to adopt proper prevention and correction strategies. The clarification of the relationship between circulating levels of uric acid and cardio-nephro-metabolic disorders in a broad sample representative of general population is critical to identify the threshold value of serum uric acid better discriminating the increased risk associated with uric acid. The Uric acid Right for heArt Health (URRAH) project has been designed to define, as primary objective, the level of uricemia above which the independent risk of cardiovascular disease may increase in a significantly manner in a general Italian population.
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