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Related Experiment Video

Updated: Feb 14, 2026

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Bilateral deep brain stimulation of the subthalamic nucleus increases pointing error during memory-guided sequential

Fabian J David1, Lisa C Goelz2,3, Ruth Z Tangonan3

  • 1Department of Physical Therapy and Human Movement Sciences, Northwestern University, 645 North Michigan Avenue, Suite 1100, Chicago, IL, 60611, USA. Fabian.J.David@northwestern.edu.

Experimental Brain Research
|February 11, 2018
PubMed
Summary

Deep brain stimulation (DBS) for Parkinson's disease enhances movement velocity but may impair finger accuracy. Bilateral STN DBS improved speed but increased errors, suggesting disrupted coordination networks.

Keywords:
Deep brain stimulationMemory-guidedParkinson diseaseSTN DBSSequential reachSubthalamic nucleus

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Area of Science:

  • Neuroscience
  • Motor Control
  • Neurological Disorders

Background:

  • Deep brain stimulation of the subthalamic nucleus (STN DBS) is a key treatment for Parkinson's disease (PD).
  • While STN DBS improves motor symptoms and movement intensity (velocity, amplitude), its effects on motor coordination are unclear.
  • Investigating the impact of bilateral STN DBS on complex motor control is crucial for optimizing PD treatment.

Purpose of the Study:

  • To examine how bilateral STN DBS affects integrative and coordinative aspects of movement in Parkinson's disease patients.
  • To assess the impact of STN DBS on eye and finger velocity and end-point accuracy during a memory-guided sequential reaching task.

Main Methods:

  • Ten Parkinson's disease patients with bilateral subthalamic stimulators participated.
  • A memory-guided sequential reaching task was performed under four conditions: DBS-OFF, DBS-LEFT, DBS-RIGHT, and DBS-BILATERAL, over four days.
  • Primary outcomes included eye/finger velocity and end-point error.

Main Results:

  • Bilateral STN DBS significantly increased eye and finger velocity compared to OFF and unilateral conditions.
  • No significant change in eye end-point error was observed with bilateral STN DBS.
  • A novel finding was increased finger end-point error with bilateral STN DBS, independent of velocity changes.

Conclusions:

  • Bilateral STN DBS may enhance basal ganglia-cortical networks for movement intensity (velocity).
  • However, it might disrupt networks essential for specific integrative and coordinative movements, like spatial accuracy.
  • Findings suggest a potential trade-off between movement speed and accuracy with bilateral STN DBS in PD.