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[Disorders of the receptor system in regulating extracellular fluid volume in patients with rheumatic heart defects]
Abstract:
The production and urinary excretion of the natriuretic factor and sodium output decreased in patients with rheumatic heart defects as left-atrial dilatation progressed and signs of circulatory insufficiency grew more apparent. It is suggested that prolonged left-atrial dilatation is associated with a fall of volume receptor sensitivity and insufficient left-atrial production of substances activating the natriuretic factor involved in abnormal water-salt metabolism in these patients.
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