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Right ventricular assistance for experimental right ventricular dysfunction.

G K Jett, R E Applebaum, R E Clark

    The Journal of Thoracic and Cardiovascular Surgery
    |August 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

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    This study demonstrates that surgically induced right ventricular dysfunction in lambs can be effectively treated with a right ventricular assist device (RVAD). The RVAD significantly improved cardiac output and hemodynamic stability, offering a potential solution for refractory right ventricular failure.

    Area of Science:

    • Cardiovascular Surgery
    • Medical Devices
    • Pediatric Cardiology

    Background:

    • Right ventricular dysfunction is a common complication in congenital heart defect correction.
    • Effective management strategies for right ventricular failure are crucial in clinical settings.

    Purpose of the Study:

    • To surgically induce right ventricular dysfunction in a neonatal lamb model.
    • To evaluate the efficacy of a right ventricular assist device (RVAD) in supporting circulation and reversing dysfunction.

    Main Methods:

    • Right ventricular hypertrophy was induced via pulmonary artery banding in 13 neonatal lambs.
    • Right ventricular dysfunction was created by performing a right ventriculotomy.
    • A pneumatic RVAD was implanted in seven animals, connecting the pulmonary artery to the right ventricular apex.

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  • Hemodynamic parameters were compared with the RVAD on and off.

    • Main Results:

    • The RVAD significantly increased cardiac output (0.72 to 2.24 L/min) and aortic systolic pressure (53 to 85 mm Hg).
    • RVAD support reduced right ventricular end-diastolic pressure (19 to 12 mm Hg) and improved left atrial pressure (7 to 11 mm Hg).
    • The model successfully replicated right ventricular dysfunction, with unassisted animals experiencing circulatory failure.

    Conclusions:

    • Surgical induction of right ventricular dysfunction is achievable in a neonatal lamb model.
    • Right ventricular assist devices can effectively reverse surgically induced right ventricular dysfunction.
    • RVADs show promise for clinical application in managing patients with severe right ventricular failure.