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Related Concept Videos

Orthogonal Trajectories01:26

Orthogonal Trajectories

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Orthogonal trajectories describe the geometric relationship between two families of curves that intersect each other at right angles. One illustrative case involves a family of parabolas that open sideways along the x-axis. These curves share a common shape but differ by a scaling parameter, resulting in a set of curves that all pass through the origin and widen at different rates.Determining Orthogonal TrajectoriesTo identify the orthogonal trajectories for these parabolas, the first step...
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Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
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Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

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Simultaneous multislice acquisition without trajectory modification for hyperpolarized 13 C experiments.

Angus Z Lau1,2, Justin Y C Lau1,2, Albert P Chen3

  • 1Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.

Magnetic Resonance in Medicine
|February 11, 2018
PubMed
Summary
This summary is machine-generated.

This study demonstrates that simultaneous multislice excitation enables large field-of-view (FOV) hyperpolarized 13C metabolic imaging. The developed method achieves high image quality and SNR, paving the way for whole-body exams.

Keywords:
13Chyperpolarizationparallel imagingsimultaneous multislice

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Area of Science:

  • Magnetic Resonance Imaging
  • Metabolic Imaging
  • Medical Physics

Background:

  • Hyperpolarized 13C metabolic imaging offers insights into cellular metabolism.
  • Current limitations include restricted field-of-view (FOV) and long acquisition times.
  • Simultaneous multislice (SMS) excitation is a promising technique to accelerate MRI acquisition.

Purpose of the Study:

  • To investigate the feasibility of large FOV hyperpolarized 13C metabolic imaging using SMS excitation.
  • To develop and validate an SMS pulse sequence for hyperpolarized 13C imaging.

Main Methods:

  • A spectral-spatial SMS excitation pulse was integrated into a 13C spiral imaging sequence.
  • Phantom and in vivo pig studies were conducted for data acquisition and image reconstruction.
  • Cardiac-gated images were acquired with 2-fold slice acceleration and reconstructed using sensitivity encoding.

Main Results:

  • SMS images with 2-fold acceleration were comparable to unaccelerated reference scans.
  • Signal-to-noise ratio (SNR) above 80% was maintained in the cardiac region.
  • High-resolution (1x1x1 cm3) images were obtained over a large FOV (48x48x24 cm3).

Conclusions:

  • SMS excitation is feasible for large FOV hyperpolarized 13C metabolic imaging.
  • This technique significantly improves imaging efficiency, potentially enabling whole-body metabolic examinations.
  • The method overcomes previous FOV limitations in hyperpolarized 13C MRI.