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Modulation of dendritic cell by pathogen antigens: Where do we stand?
Gabriela Peron1, Livia de Lima Thomaz1, Larissa Camargo da Rosa1
1Department of Structural and Functional Biology, Institute of Biology, University of Campinas, UNICAMP, Campinas, SP, Brazil.
Immunology Letters
|February 11, 2018
Summary
Pathogen-modulated dendritic cells (DCs) can be harnessed for therapeutic benefits. This review explores their use in vaccination and treating inflammatory disorders.
Area of Science:
- Immunology
- Cell Biology
Background:
- Dendritic cells (DCs) are crucial for adaptive immunity, activating T cells upon pathogen recognition.
- DCs influence T helper (Th) cell differentiation into various subsets (Th1, Th2, Th17, Th9, Treg).
- Pathogens can induce tolerogenic DCs (tolDCs) by dampening DC maturation and activation.
Purpose of the Study:
- To review the application of pathogen-antigen modulated DCs and tolDCs.
- To explore their prophylactic and therapeutic potential in vaccination and inflammatory disease management.
Main Methods:
- Review of existing literature on DC modulation by pathogen-derived antigens.
- Analysis of studies utilizing modified DCs for immune response manipulation.
Main Results:
- Pathogen-antigen interactions can lead to DCs with a tolerogenic profile (tolDCs).
- While potentially hindering infection control, tolDCs offer therapeutic avenues for inflammatory conditions.
- Modulated DCs show promise in prophylactic and therapeutic vaccination strategies.
Conclusions:
- Pathogen-modified DCs, particularly tolDCs, represent a versatile tool in immunotherapy.
- Harnessing these cells can lead to novel strategies for infectious disease prevention and autoimmune disease treatment.
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