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Updated: Feb 14, 2026

Three-dimensional Alginate-bead Culture of Human Pituitary Adenoma Cells
Published on: February 18, 2016
Subclinical haemorrhage in non-functional adenomas
H Cebula1, E Fasciglione2, M D N Santin1
1Department of Neurosurgery, hôpital Hautepierre, 1, avenue Molière, 67100 Strasbourg, France.
Subclinical hemorrhage (SH) occurred in 34.38% of non-functional pituitary adenomas (NFAs) without identifiable risk factors. Patients with SH showed a higher incidence of pituitary deficiency at diagnosis.
Area of Science:
- Endocrinology
- Neurosurgery
- Radiology
Background:
- Subclinical hemorrhage (SH) in non-functional pituitary adenomas (NFAs) is not well understood.
- Prevalence and risk factors for SH in NFAs require further investigation.
Purpose of the Study:
- To determine the incidence of SH in NFAs.
- To identify potential risk factors associated with SH.
- To evaluate the impact of SH on pituitary function.
Main Methods:
- Retrospective analysis of 64 adult patients with confirmed NFAs.
- Diagnosis of SH based on pituitary MRI, with senior neuroradiologist review.
- Patients divided into SH and control groups to assess risk factors and pituitary function.
Main Results:
- SH was diagnosed in 34.38% of patients.
- No significant risk factors (age, sex, tumor size, comorbidities, medications) were associated with SH.
- Pituitary deficiency was significantly more frequent in the SH group (45.45%) compared to the control group (19.04%).
Conclusions:
- SH is a common finding in NFAs, observed in over a third of cases.
- No specific risk factors were identified for SH in this cohort.
- SH in NFAs is associated with an increased risk of pituitary dysfunction at diagnosis.
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