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Updated: Feb 14, 2026

Author Spotlight: Evaluating Traditional Chinese Therapy for Ankylosing Spondylitis in Mice
Published on: October 27, 2023
Immune cells involved in the pathogenesis of ankylosing spondylitis
Alireza Rezaiemanesh1, Mohsen Abdolmaleki2, Kamal Abdolmohammadi2
1Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Abstract:
Ankylosing spondylitis (AS) is an inflammatory autoimmune disease. AS is a prototype form of spondyloarthropathies (SpA). The precise etiology of AS has not been fully understood. But Inflammation has a critical role in the pathogenesis of the disease. The immune system by various cells, secreted-mediators and markers manage and regulate the immune responses and inflammation. Every factor which disturbed this regulation and hemostasis can cause chronic inflammation. In this review, we discussed the role of several innate and adaptive immune cells involved in the triggering, initiation, development, and regulation of AS.
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