[Biomonitoring application in the exposome assessment].

Area of Science:

• Environmental Health
• Toxicology
• Biochemistry

Background:

• Biomonitoring assesses internal and environmental exposures using biomarkers.
• It is crucial for evaluating disease risk linked to biological alternations.
• Advancements in detection technology have expanded biomonitoring capabilities.

Purpose of the Study:

• To differentiate between traditional targeted monitoring and non-targeted exposomic approaches.
• To highlight the importance of integrating both methods for comprehensive exposure assessment.
• To emphasize the role of biomonitoring in understanding lifespan exposures and health outcomes.

Main Methods:

• Utilizing high throughput, broad spectrum, and efficient screening technologies.
• Employing traditional biological monitoring (targeted analysis).
• Implementing non-targeted monitoring analysis (exposomic approaches).

Main Results:

• Exposomic approaches can theoretically encompass all exposures of potential health significance.
• Hybrid approaches combining traditional and non-traditional methods are essential.
• Developing methods for low abundance chemicals and differentiating endogenous/exogenous sources is key.

Conclusions:

• Biomonitoring, encompassing both targeted and exposomic strategies, is vital for characterizing health outcomes and exposures.
• Integrating advanced techniques and bioinformatics enhances our understanding of complex exposures.
• This comprehensive approach supports precise disease prevention and intervention under the exposomic model.