Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH301:11

ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3

7.6K
All ortho–para directors, excluding halogens, are activating groups. These groups donate electrons to the ring, making the ring carbons electron-rich. Consequently, the reactivity of the aromatic ring towards electrophilic substitution increases. For instance, the nitration of anisole is about 10,000 times faster than the nitration of benzene. The electron-donating effect of the methoxy group in anisole activates the ortho and para positions on the ring and stabilizes the corresponding...
7.6K
Piaget's Stage 3 of Cognitive Development01:17

Piaget's Stage 3 of Cognitive Development

1.1K
During Piaget's concrete operational stage, from ages 7 to 11, children exhibit a marked increase in logical thinking skills, specifically in relation to tangible, real-world events. This stage is characterized by the development of several essential cognitive concepts, including conservation, reversibility, and classification, all of which support the child's evolving capacity for structured thought.
Conservation and Constancy of Quantity
A significant cognitive milestone in the...
1.1K
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

715
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
715
Persuasion Strategies01:52

Persuasion Strategies

43.6K
Researchers have tested many persuasion strategies, including the foot-in-the door and the door-in-the-face techniques, in a variety of contexts. Ultimately, the principles are effective in selling products and changing people’s attitude, ideas, and behaviors (Cialdini & Goldstein, 2004).
43.6K
Coping Strategies: Problem Focused01:27

Coping Strategies: Problem Focused

538
Coping strategies are methods people use to manage, tolerate, or reduce the effects of stressors. These strategies involve both behavioral and psychological actions to handle stressful situations. One common approach is problem-focused coping, which aims to change or eliminate the source of stress rather than merely addressing its consequences. This method involves taking direct action to resolve the issue causing stress.
For example, consider a student who struggles to understand their...
538
Strategies of Self-Presentation II: Self-Verification01:17

Strategies of Self-Presentation II: Self-Verification

208
Self-verification is a fundamental psychological drive wherein individuals seek affirmation of their self-concept from others, striving for consistency between their internal self-view and external perceptions. This drive operates even when the self-concept is negative, influencing interpersonal behavior and feedback preferences in complex and often counterintuitive ways. Unlike the self-enhancement motive, which seeks positive evaluations, self-verification prioritizes coherence and...
208

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ligand Design Enables Cu-Catalyzed Etherification of Aryl Bromides Using Mild Bases.

Organic letters·2026
Same author

Enantioselective β-C(sp<sup>3</sup>)-H Nucleophilic Tosylation of Native Amides: A Synthetic Platform for Chiral Methyl Stereocenters.

Journal of the American Chemical Society·2025
Same author

Cu-Catalyzed Amination of Base-Sensitive Aryl Bromides and the Chemoselective N- and O-Arylation of Amino Alcohols.

Journal of the American Chemical Society·2024
Same author

Room-Temperature Copper-Catalyzed Etherification of Aryl Bromides.

Angewandte Chemie (International ed. in English)·2024
Same author

Stereocontrolled access to thioisosteres of nucleoside di- and triphosphates.

Nature chemistry·2023
Same author

Kinetic and Thermodynamic Considerations in the Rh-Catalyzed Enantioselective Hydrogenation of 2-Pyridyl-Substituted Alkenes.

ACS catalysis·2023
Same journal

Direct Synthesis of <i>N</i>-Acylhydrazones from <i>N</i>-Substituted Hydrazines, Aldehydes, and Carboxylic Acids via Preferential Imine Formation and Selective Secondary Amine Monoacylation.

The Journal of organic chemistry·2026
Same journal

Rh(III)-Catalyzed, <i>N</i>-Amino-Directed C-H Coupling with 2-Oxo-3-butynoates to Benzodiazepines.

The Journal of organic chemistry·2026
Same journal

Acetic Acid-Assisted Electrochemical <i>Ipso</i>-Nitration of Aryl Borides Using Ferric Nitrate Nonahydrate.

The Journal of organic chemistry·2026
Same journal

How Intramolecular Epoxide-Opening Cascades Generate Polyether Ionophores, Marine Ladder Polyethers, and Oxasqualenoids.

The Journal of organic chemistry·2026
Same journal

An Efficient and Scalable Approach to Functionalized Urea via Bench-Stable Amidine Building Blocks.

The Journal of organic chemistry·2026
Same journal

Switchable <i>N</i>-Haloethylation and C-H Halogenation of NH-Enaminones with 1,2-Dihaloethanes.

The Journal of organic chemistry·2026
See all related articles

Related Experiment Video

Updated: Feb 14, 2026

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3
08:36

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3

Published on: April 7, 2023

1.6K

Strategy To Prepare 3-Bromo- and 3-Chloropyrazoles.

Richard J Fox1, Michael A Schmidt1, Martin D Eastgate1

  • 1Chemical & Synthetic Development, Bristol-Myers Squibb , 1 Squibb Drive, New Brunswick, New Jersey 08903, United States.

The Journal of Organic Chemistry
|February 13, 2018
PubMed
Summary
This summary is machine-generated.

Researchers developed a new three-step method for synthesizing substituted 3-halopyrazoles. This strategy offers good yields and regiocontrol for preparing brominated and chlorinated pyrazole compounds.

More Related Videos

3' End Sequencing Library Preparation with A-seq2
12:01

3' End Sequencing Library Preparation with A-seq2

Published on: October 10, 2017

11.1K
Monovalent Cation Doping of CH3NH3PbI3 for Efficient Perovskite Solar Cells
08:30

Monovalent Cation Doping of CH3NH3PbI3 for Efficient Perovskite Solar Cells

Published on: March 19, 2017

17.2K

Related Experiment Videos

Last Updated: Feb 14, 2026

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3
08:36

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3

Published on: April 7, 2023

1.6K
3' End Sequencing Library Preparation with A-seq2
12:01

3' End Sequencing Library Preparation with A-seq2

Published on: October 10, 2017

11.1K
Monovalent Cation Doping of CH3NH3PbI3 for Efficient Perovskite Solar Cells
08:30

Monovalent Cation Doping of CH3NH3PbI3 for Efficient Perovskite Solar Cells

Published on: March 19, 2017

17.2K

Area of Science:

  • Organic Chemistry
  • Heterocyclic Chemistry

Background:

  • Pyrazole derivatives are important scaffolds in medicinal chemistry and materials science.
  • Efficient synthesis of substituted pyrazoles, particularly halogenated ones, is crucial for further derivatization.

Purpose of the Study:

  • To develop a general and efficient strategy for preparing substituted 3-bromo- and 3-chloropyrazoles.
  • To achieve good to excellent yields and regiocontrol in the synthesis of 3-halopyrazoles.

Main Methods:

  • A three-step synthesis involving condensation of crotonates or β-chloro carboxylic acids with hydrazines.
  • Subsequent halogenation and oxidation steps.
  • Development of optimized condensation and oxidation protocols.

Main Results:

  • Successful preparation of a wide variety of 3-halopyrazoles.
  • Achieved good to excellent yields for the target compounds.
  • Demonstrated effective regiocontrol during the synthesis.

Conclusions:

  • The described three-step method provides a versatile approach for synthesizing substituted 3-halopyrazoles.
  • The developed protocols are suitable for preparing diverse 3-halopyrazole structures with high efficiency.